APPLIED
BIOPHARMACEUTICS & PHARMACOKINETICS
FIFTH EDITION
By
LEON SHARGEL
SUSANNA WU-PONG
ANDREW B.C. YU
CHM (ELECTRONIC FORMAT/E-BOOK)
Copyright © Mc-Graw Hill ACCESS PHARMACY
CONTENTS
Chapter 1. Introduction to Biopharmaceutics and Pharmacokinetics
Chapter 2. Mathematical Fundamentals in Pharmacokinetics
Chapter 3. One-Compartment Open Model: Intravenous Bolus
Administration
Chapter 4. Multicompartment Models: Intravenous Bolus
Administration
Chapter 5. Intravenous Infusion
Chapter 6. Drug Elimination and Clearance
Chapter 7. Pharmacokinetics of Oral Absorption
Chapter 8. Multiple-Dosage Regimens
Chapter 9. Nonlinear Pharmacokinetics
Chapter 10. Physiologic Drug Distribution and Protein
Binding
Chapter 11. Hepatic Elimination of Drugs
Chapter 12. Pharmacogenetics
Chapter 13. Physiologic Factors Related to Drug
Absorption
Chapter 14. Biopharmaceutic Considerations in Drug Product
Design
Chapter 15. Bioavailability and Bioequivalence
Chapter 16. Impact of Drug Product Quality and Biopharmaceutics on
Clinical Efficacy
Chapter 17. Modified-Release Drug Products
Chapter 18. Targeted Drug Delivery Systems and Biotechnological
Products
Chapter 19. Relationship between Pharmacokinetics and
Pharmacodynamics
Chapter 20. Application of Pharmacokinetics to Clinical
Situations
Chapter 21. Dose Adjustment in Renal and Hepatic
Disease
Chapter 22. Physiologic Pharmacokinetic Models, Mean Residence Time,
and Statistical Moment Theory
Appendix A. Statistics
Appendix B. Applications of Computers in
Pharmacokinetics
Appendix C. Solutions to Frequently Asked Questions (FAQ) and
Learning Questions
Appendix D. Guiding Principles for Human and Animal
Research
Appendix E. Pharmacokinetic and Pharmacodynamic Parameters for
Selected Drugs
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